The Topoisomerase II beta Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to TOP2B. This antibody recognizes Human, and Rat antigen. The Topoisomerase II beta Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene